THE BASIC PRINCIPLES OF FENTANYL AND XYLAZINE

phenytoin will reduce the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead into a decrease in fentanyl plasma concentrations, lack of efficacy or, possibly, growth of a withdrawal syndrome within a client who may have fo